Tear Mixing; Epithelial Barrier Function; Contact Lens Extended Wear
Professor Polse's research develops from a strong interest in clinical practice, particularly in the area of cornea and contact lenses. Polse has adopted a research strategy that applies his clinical experience to studies both in the laboratory and clinical settings. In collaboration with several of his Berkeley colleagues, Polse has investigated methodological and laboratory strategies for non-invasive in vivo assessment of human corneal function, focusing on the effects of disease, environment, and medical intervention on corneal structure and function. He has successfully completed two NIH-funded clinical trials and plans more clinical research into the effects of contact lens/corneal interactions.
These studies and Polse's experience in clinical research will give BCSDP trainees an opportunity to conduct research under the mentorship of an individual who has had considerable experience and success with both laboratory and clinical trials patient-based research. Currently, the Polse lab focuses on understanding interactions between the cornea and contact lens. Funded studies are underway that are designed to test strategies for improving tear flow and maintaining normal ocular surface characteristics under a contact lens. These studies will provide an excellent environment for BCSDP trainees to develop expertise in clinical trial methodology.
