Neural bases of high-level cognitive processes
Dr. D'Esposito's research focuses on investigating the neural bases of high-level cognitive processes such as working memory and executive control, achieved through several different experimental approaches and methodologies. First, functional MRI is used to identify the neural substrates and temporal dynamics of various cognitive processes, especially those supported by the prefrontal cortex, in normal human subjects. Second, the role of the dopaminergic system in working memory and frontal lobe function is investigated with pharmacological studies during which direct dopaminergic agonists are administered to normal human subjects, as well as patients with neurological disorders such as stroke and dementia. Third, behavioral studies in patient populations with frontal lobe dysfunction (e.g., stroke, head injury, Parkinson's disease) are performed in order to further understand the mechanisms that underlie working memory. Finally, methodological research is aimed at developing improved techniques for the acquisition and the analysis of fMRI data, as well as towards understanding the physiological basis of the BOLD signal. BCSDP trainees would therefore have opportunities to conduct research in all four areas.
